Cobram Crime Investigation Unit detectives are appealing for witnesses following an armed robbery at a service station in Cobram last night.

Investigators have been told an offender wearing a balaclava and gloves entered the service station at the corner of Station Street and the Murray Valley Highway about 10.30pm.

The offender, believed to be a male and armed with a knife, made demands for cash from the female staff member.

The staff member complied and handed over an amount of cash and cigarettes.

The offender ran from the store and was seen running to an awaiting vehicle on Station Street.

The vehicle, which was driven by a second offender, was last seen travelling north along Station Street.

No one was injured during the incident.