Armed Crime Squad detectives have arrested four men following an armed robbery at an Essendon hotel this morning.

Police were called to the Keilor Road venue following reports two males entered the hotel armed with firearm and a knife about 1.15am.

The men made threats towards staff before making off with an amount of money.

Two of the men, aged 21 from Broadmeadows have been released pending further enquiries.

A 20-year-old from Broadmeadows and a 23-year-old from Roxburgh Park remain in custody, assisting police with their enquiries, following their arrest at a motel in Sydney Road Coburg this morning.

Armed Crime Squad detectives are investigating whether the incident is linked with a series of gaming venue armed robberies in the northern and western suburbs.

No one was injured during the incident and investigations into the series of armed robberies continue.