Fraud and Extortion Squad detectives have charged two males following an investigation into credit card skimming in regional Victoria.

Police arrested the two men, who were travelling in a car along the Hume Highway near Benalla, yesterday afternoon.

Investigators also seized skimming devices and an amount of cash which were found in the vehicle.

The arrests follow a number of alleged incidents in regional Victoria in recent months, notably in Heyfield, Paynesville, Warrnambool and Hamilton.

The two men, aged 35 and 37 from New South Wales, have been charged with conspiracy to defraud.

They are set to appear at Melbourne County Court at a later date.