Police are currently at the scene of an aggravated robbery at a chemist on Whites Road, Salisbury North.
At about 5.30pm two men entered the pharmacy allegedly armed with machetes and demanded cash.
The men left with an amount of cash and drugs and were last seen running through an alley opposite the chemist.
The suspects are described as being of aboriginal appearance with one wearing a dark hooded top and dark track pants and the other a white hooded top and dark track pants.
No one has been injured.