A bottle shop at Fullarton was broken into overnight, the second time the business has been targeted this week.
Police and security patrols responded to an alarm activation at the Cellarbrations store on Fullarton Road just after 1.30am but the suspects had fled just prior to police arrival.
CCTV from the premises revealed two men, both Caucasian, wearing black hoodies, had broken into the premises and stolen a quantity of alcohol.
A police dog tracked their scent to Arthur Street, Fullarton, where it is thought the suspects had a car waiting.
Police ask anyone with information about this incident or saw any vehicles parked in Arthur Street overnight to contact BankSA Crime Stoppers on 1800 333 000 or online at www.sa.crimestoppers.com.au.
Police are also investigating two other nearby break-ins overnight.
At about 2.30am, a chemist on Stuart Road, Dulwich was broken into.
Then at about 3.45am, a break-in occurred at a vet clinic on Kensington Road, Rose Park, however nothing was stolen during either break-in.